THE MORGRIDGE INSTITUTE

Virology: unlocking the secrets of virus-host interactions to better protect human health- advance practical understanding, prevention and treatment of viruses and their diseases.- enhance understanding of the biology of healthy cells and tissues.- develop new tools derived from viruses for use in biotechnology, nanotechnology and medicine.

Research computing: expending computing power to address new questions in biology- develop a cyber-infrastructure that provides high throughput computing and fosters collaborative work with the medical science partners.- develop software assurance marketplace that aids open source software developers and software assurance tools that developers can create a more secure cyberinfrastructure by offering the capacity needed to continuously test and "rebuild" the code underlying critical infrastructure applications.

General science:- bioethics: addressing emerging ethical issues and building a culture of responsible science.- hemostasis: initiation and regulation of protease cascades, which govern a variety of essential physiological processes from blood clotting to mechanisms of cell death.

Metabolism:- elucidating the chemistry of life and its disruption in human disease- mitochondria and disease: unlocking function of the mitochondria, or "cellular powerhouse," to understand its role in more than 150 diseases, including parkinson's, diabetes, and cancer.- orphan proteins: establishing a research platform to study the more than 100 proteins - nearly one-quarter of the mammalian mitochondrial proteome - that have a yet undiscovered biochemical function.- coenzyme q: integrating various biochemical, genetic and structural biology approaches to further elucidate the steps of coenzyme q, whose deficiency is associated with multiple human diseases.

Community engagement: - engage the community in science education.