Prevent Alzheimers Disease 2020

Alzheimers disease poses a significant burden on a global scale which has led to an enormous investment in research to find a cure. However despite these efforts there are very few medications available for people with dementia. The search for new interventions for Alzheimers disease is challenging because the exact relationship between the symptoms of the disease and its neurobiology is not yet fully understood. The diseases heterogeneity complex biological and environmental interactions multiple nonlinear timescales and a lack of modeling systems to integrate complex relationships further complicate this effort. To address these challenges the Calcium System Theory of Alzheimers Disease CAST-AD workgroup aims to design a unified systems theory. The group aims to create new foundational models to study protein dynamics and aggregation in neurodegenerative diseases. These models will be trained using supercomputing and hybrid super- and quantum-computing to simulate large data sets of proteins. The project will establish and validate foundational models using proteins such as bioluminescent enzymes to provide an easy functional readout. The group will then apply these models to crucial proteins and peptides involved in neurodegenerative diseases.

Brain vascular diseases are linked to the onset of dementia. PAD 20 20 coordinated a global task force to assess the efficacy of utilizing approved vascular health interventions to prevent or treat dementia. Evidence shows that modifying lifestyle factors such as physical activity healthy diet and proper sodium intake can improve vascular health and offer an opportunity for brain health. The initiative aims to identify tangible opportunities to provide financial or technical resources to sustain multi-year activities and evaluate approaches that may accelerate the development of new interventions. The project will focus on developing strategies to provide affordable accessible and equitable dementia prevention through widely prescribed medications for various vascular and metabolic disorders. There is a clear need for robust clinical evidence to support this public health approach.